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Bactrim - a combined drug, containing two active ingredients: sulfanamide drug sulfamethoxazole and derivative of diaminopyrimidine - trimethoprimum. Colibacillus life activity oppresses that leads to reduction of synthesis of thymine, riboflavinum, niacin, etc. group B vitamins in intestines. Duration of therapeutic effect makes 7 years.

Sulfamethoxazole trimethoprim over the counter. (Diphenhydramine was included when possible and had a dose of 4 mg.) At the time of study, these 2 drugs were still commonly used to treat a wide variety of acute upper respiratory tract infection (URTI) problems. One of these studies compared the effectiveness of diphenhydramine with imipenem (another common medication at the time) with those of cetuximab, a non-nucleoside reverse transcriptase inhibitor (NNRTI) drug, both used in combination (see Figure and for the complete study). Both drug combinations were effective against both the primary infection and secondary infection. In one trial with 8 patients, diphenhydramine was approximately 2-fold as effective imipenem, whereas in another trial with 10 patients, the effect was close to 10-fold in favor of imipenem. While the clinical trial results from early '90s support the use of cetuximab and diph